Many orientalists have presented their views and theories on the Shiite school and its characteristics. One of them who has a special view on this matter is Mrs. Patricia Crone. Her views are important because she challenges the Shiite school - due to the belief in the existence of infallible Imams (peace be upon them) after the Holy Prophet (peace be upon him and his family) and following them to achieve happiness - and considers them from the beginning of their emergence to the contemporary era to be a clear and objective manifestation of Gnostic thought and its promoter; because from her point of view, the Shiites, like the Gnostics, felt alienated from their environment, so they relied on the Holy Family, who, from the Shiite point of view, were the bearers of "transcendent knowledge". The following article, which is organized in a descriptive-analytical manner, expresses and criticizes the views of Mrs. Crone and proves that the Shiite school has not only never been a propagator and manifestation of Gnostic thought, but is fundamentally different from it and even opposed to it; Because Gnostic thought considers God as a partner and believes in the existence of multiple gods in the creation of the world, while the Shiite school emphasizes the unity of God in all areas and considers the Imams and divine saints only as intermediaries of grace and blessings between servants and God. Therefore, the most fundamental oppositions between the two can be seen in "monotheism versus dualism", "positive view of the world versus negative view", and "belief in the Sharia versus disregard for it".